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Consequently, PRRs have emerged as promising targets for cancer therapy
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539,540 Over the past two decades, innate immune PRRs have emerged as essential regulators, modulating a wide range of cellular responses in both immune cells within the TME and directly within cancer cells, with effects that can either inhibit or promote tumor growth
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This pathway is activated when cells experience stress related to the accumulation of unfolded proteins in the ER
Nuttall SL, Martin U, Sinclair AJ, Kendall MJ
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